BDBM50137566 1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinolizin-2-yl)-1,3-dihydro-benzoimidazol-2-one::CHEMBL52604::SR-14138

SMILES CCn1c2ccccc2n([C@@H]2CCN3[C@H](CCC[C@H]3c3ccccc3)C2)c1=O

InChI Key InChIKey=RTCXPSZQJKHURF-NJYVYQBISA-N

Data  4 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50137566   

TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50137566(1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinoliz...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for human opioid receptor mu 1 using [3H]- DAMGO as radioligand transfected into CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50137566(1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinoliz...)
Affinity DataKi:  20nMAssay Description:Binding affinity for human nociceptin (NOP) receptor using [3H]N/OFQ as radioligand transfected into CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50137566(1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinoliz...)
Affinity DataKi:  23nMAssay Description:Binding affinity for human opioid receptor kappa 1 using [3H]- U-69,593 as radioligand transfected into CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50137566(1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinoliz...)
Affinity DataKi:  1.49E+3nMAssay Description:Binding affinity for human opioid receptor delta 1 using [3H]- CL-DPDPE as radioligand transfected into CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50137566(1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinoliz...)
Affinity DataEC50:  210nMAssay Description:Concentration required to stimulate [35S]GTP-gamma-S, binding to human opioid receptor kappa 1 in cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50137566(1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinoliz...)
Affinity DataEC50:  105nMAssay Description:Concentration required to stimulate [35S]GTP-gamma-S, binding to human opioid receptor mu 1 in cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50137566(1-Ethyl-3-((2R,6S,9aR)-6-phenyl-octahydro-quinoliz...)
Affinity DataEC50:  165nMAssay Description:Concentration required to stimulate [35S]GTP-gamma-S, binding to human NOP receptor in cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed