BDBM50144435 1-methyl-5-[2'-oxospiro[cyclohexane-1,3'-(2',3'-dihydro-1'H-indole)]-5-yl]-1H-2-pyrrolecarbonitrile::5-(spiro[cyclohexane-1,3'-[3H]indole]-2'-oxo-5'-yl)-1H-pyrrole-1-methyl-2-carbonitrile::CHEMBL305298

SMILES Cn1c(ccc1-c1ccc2NC(=O)C3(CCCCC3)c2c1)C#N

InChI Key InChIKey=WMIPEGGWIZEEMY-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50144435   

TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50144435(1-methyl-5-[2'-oxospiro[cyclohexane-1,3'-(2',3'-di...)
Affinity DataIC50: >3.00E+3nMAssay Description:Ability to block progesterone induced alkaline phosphatase activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50144435(1-methyl-5-[2'-oxospiro[cyclohexane-1,3'-(2',3'-di...)
Affinity DataEC50:  2.30nMAssay Description:Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50144435(1-methyl-5-[2'-oxospiro[cyclohexane-1,3'-(2',3'-di...)
Affinity DataIC50:  3.30nMAssay Description:Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50144435(1-methyl-5-[2'-oxospiro[cyclohexane-1,3'-(2',3'-di...)
Affinity DataEC50:  2.80nMAssay Description:Agonistic activity measures the ability to induce alkaline phosphatase in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed