BDBM50148827 CHEMBL3769975

SMILES COc1ccc2ccccc2c1Cn1cnc2sc3CC(CCc3c2c1=O)NCc1cccnc1

InChI Key InChIKey=UEJBOCXPGHSONP-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50148827   

TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataKi:  620nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using tubulin-K40 peptide in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of human SIRT2 using RHKK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SIRT5 (37 to 310 end residues) expressed in Escherichia coli using Ac-K(Succ)-AMC as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli in presence of NAD+ by enzyme coup...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human SIRT1 using RHKK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50148827(CHEMBL3769975)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged SIRT3 (101 to 399 residues) expressed in Escherichia coli using p53 derived (379 to 382 residue...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed