BDBM50149711 5-Iodo-thiophene-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide::CHEMBL182652

SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1

InChI Key InChIKey=HBYKTDPONPUZPO-UHFFFAOYSA-N

Data  6 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50149711   

TargetD(3) dopamine receptor(Homo sapiens (Human))
University of Erlangen-Nuremberg

Curated by ChEMBL
LigandPNGBDBM50149711(5-Iodo-thiophene-2-carboxylic acid {4-[4-(2-methox...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1
Show InChI InChI=1S/C20H26IN3O2S/c1-26-17-7-3-2-6-16(17)24-14-12-23(13-15-24)11-5-4-10-22-20(25)18-8-9-19(21)27-18/h2-3,6-9H,4-5,10-15H2,1H3,(H,22,25)
Affinity DataKi:  2.40nMAssay Description:Binding affinity towards human D3 receptor using [3H]-spiperone expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Erlangen-Nuremberg

Curated by ChEMBL
LigandPNGBDBM50149711(5-Iodo-thiophene-2-carboxylic acid {4-[4-(2-methox...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1
Show InChI InChI=1S/C20H26IN3O2S/c1-26-17-7-3-2-6-16(17)24-14-12-23(13-15-24)11-5-4-10-22-20(25)18-8-9-19(21)27-18/h2-3,6-9H,4-5,10-15H2,1H3,(H,22,25)
Affinity DataKi:  10nMAssay Description:Binding affinity towards 5-HT1A receptor from porcine cortical membranes using [3H]-8-OH-DPATMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
University of Erlangen-Nuremberg

Curated by ChEMBL
LigandPNGBDBM50149711(5-Iodo-thiophene-2-carboxylic acid {4-[4-(2-methox...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1
Show InChI InChI=1S/C20H26IN3O2S/c1-26-17-7-3-2-6-16(17)24-14-12-23(13-15-24)11-5-4-10-22-20(25)18-8-9-19(21)27-18/h2-3,6-9H,4-5,10-15H2,1H3,(H,22,25)
Affinity DataKi:  31nMAssay Description:Binding affinity towards human D4.4 receptor using [3H]-spiperone expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Erlangen-Nuremberg

Curated by ChEMBL
LigandPNGBDBM50149711(5-Iodo-thiophene-2-carboxylic acid {4-[4-(2-methox...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1
Show InChI InChI=1S/C20H26IN3O2S/c1-26-17-7-3-2-6-16(17)24-14-12-23(13-15-24)11-5-4-10-22-20(25)18-8-9-19(21)27-18/h2-3,6-9H,4-5,10-15H2,1H3,(H,22,25)
Affinity DataKi:  35nMAssay Description:Binding affinity towards human D2 short receptor using [3H]-spiperone expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Erlangen-Nuremberg

Curated by ChEMBL
LigandPNGBDBM50149711(5-Iodo-thiophene-2-carboxylic acid {4-[4-(2-methox...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1
Show InChI InChI=1S/C20H26IN3O2S/c1-26-17-7-3-2-6-16(17)24-14-12-23(13-15-24)11-5-4-10-22-20(25)18-8-9-19(21)27-18/h2-3,6-9H,4-5,10-15H2,1H3,(H,22,25)
Affinity DataKi:  75nMAssay Description:Binding affinity towards human D2 long receptor using [3H]-spiperone expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Sus scrofa)
University of Erlangen-Nuremberg

Curated by ChEMBL
LigandPNGBDBM50149711(5-Iodo-thiophene-2-carboxylic acid {4-[4-(2-methox...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1
Show InChI InChI=1S/C20H26IN3O2S/c1-26-17-7-3-2-6-16(17)24-14-12-23(13-15-24)11-5-4-10-22-20(25)18-8-9-19(21)27-18/h2-3,6-9H,4-5,10-15H2,1H3,(H,22,25)
Affinity DataKi:  600nMAssay Description:Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390More data for this Ligand-Target Pair