BDBM50150101 CHEMBL419240::[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]-[3-(5-fluoro-1H-indol-3-yl)-propyl]-amine

SMILES Fc1ccc2[nH]cc(CCCNCCOc3cccc4OCCOc34)c2c1

InChI Key InChIKey=KHNYULBQTPNFTQ-UHFFFAOYSA-N

Data  2 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50150101   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150101(CHEMBL419240 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150101(CHEMBL419240 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150101(CHEMBL419240 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition concentration against [3H]-5-HT uptake by human serotonin transporter in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150101(CHEMBL419240 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataEC50:  1.10nMAssay Description:Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150101(CHEMBL419240 | [2-(2,3-Dihydro-benzo[1,4]dioxin-5-...)
Affinity DataEC50:  15.7nMAssay Description:Effective concentration against binding of radioligand [35]GTPgammaS in CHO cells expressing human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed