BDBM50150818 CHEMBL3774575

SMILES CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)c1

InChI Key InChIKey=HYQBRUSSCIAOOD-UHFFFAOYSA-N

Data  2 IC50  10 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50150818   

TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  31nMAssay Description:Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair
TargetPeregrin(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  14nMAssay Description:Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  1.30nMAssay Description:Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair
TargetPeregrin(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  2.10nMAssay Description:Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 1(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  12nMAssay Description:Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataIC50:  150nMAssay Description:Inhibition of TRIM24 (unknown origin) measured alphascreen assayMore data for this Ligand-Target Pair
TargetBromodomain adjacent to zinc finger domain protein 2B(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  400nMAssay Description:Inhibition of KDM6B (unknown origin) using biotin-H3K27me3 (21 to 44 residues) as substrate preincubated for 15 mins followed by substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  1.80E+3nMAssay Description:Inhibition of KDM6B (unknown origin) using biotin-H3K27me3 (21 to 44 residues) as substrate preincubated for 15 mins followed by substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of KDM6B (unknown origin) using biotin-H3K27me3 (21 to 44 residues) as substrate preincubated for 15 mins followed by substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataEC50:  50nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50150818(CHEMBL3774575)
Affinity DataKd:  27nMAssay Description:Inhibition of KDM3A (unknown origin) using biotin-H3K9me2 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed