BDBM50151891 CHEMBL273869::{2-(2,2-Diphenyl-ethylamino)-5-[4-(4-methyl-piperazine-1-carbonyl)-piperidine-1-sulfonyl]-phenyl}-morpholin-4-yl-methanone

SMILES CN1CCN(CC1)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc(NCC(c2ccccc2)c2ccccc2)c(c1)C(=O)N1CCOCC1

InChI Key InChIKey=VODUCDWVPSEMSZ-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50151891   

TargetB1 bradykinin receptor(Macaca mulatta)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50151891(CHEMBL273869 | {2-(2,2-Diphenyl-ethylamino)-5-[4-(...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity to monkey bradykinin B1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50151891(CHEMBL273869 | {2-(2,2-Diphenyl-ethylamino)-5-[4-(...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50151891(CHEMBL273869 | {2-(2,2-Diphenyl-ethylamino)-5-[4-(...)
Affinity DataKi:  10nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50151891(CHEMBL273869 | {2-(2,2-Diphenyl-ethylamino)-5-[4-(...)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed