BDBM50152524 (S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyrazol-5-ylamino)-1,2-dioxoheptan-3-ylcarbamate::CHEMBL185097::[(S)-1-(2H-Pyrazol-3-ylaminooxalyl)-pentyl]-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester::[1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE

SMILES CCCC[C@H](NC(=O)OCC1(Cc2ccc(F)cc2)CCC1)C(=O)C(=O)Nc1ccn[nH]1

InChI Key InChIKey=QTPYRNAKLBXKNP-SFHVURJKSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50152524   

TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50: >500nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50:  330nMAssay Description:Inhibition of 5 uM Cbz-Phe-Arg-AMC human cathepsin L in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50:  0.832nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50: >500nMAssay Description:Inhibition of 10 uM Cbz-Phe-Arg-AMC binding to human cathepsin B in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of 10 uM Cbz-Val-Val-Arg-AMC binding to human cathepsin S in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed