BDBM50153878 CHEMBL186580::N-[5-(6,7-Dimethoxy-quinazolin-4-ylamino)-2,4-difluoro-phenyl]-benzamide

SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)c2cc1OC

InChI Key InChIKey=RDRNBLXUDTUCRQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50153878   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153878(CHEMBL186580 | N-[5-(6,7-Dimethoxy-quinazolin-4-yl...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration against alpha mitogen activated protein kinase p38 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153878(CHEMBL186580 | N-[5-(6,7-Dimethoxy-quinazolin-4-yl...)
Affinity DataIC50:  490nMAssay Description:Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed