BDBM50154591 6-Bromo-quinolin-2-ylamine::CHEMBL189197

SMILES Nc1ccc2cc(Br)ccc2n1

InChI Key InChIKey=GSKICCPQEZRQEC-UHFFFAOYSA-N

Data  1 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50154591   

TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50154591(6-Bromo-quinolin-2-ylamine | CHEMBL189197)
Affinity DataKd:  2.66E+5nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase(Mus musculus)
The University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50154591(6-Bromo-quinolin-2-ylamine | CHEMBL189197)
Affinity DataEC50:  5.80E+4nMAssay Description:Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50154591(6-Bromo-quinolin-2-ylamine | CHEMBL189197)
Affinity DataIC50:  3.38E+5nMAssay Description:Inhibition of BACE1 using 19F-labeled EVNLDAEF(CF3) as substrate after 20 mins by NMR spectrometeryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed