BDBM50156504 (1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid 4-fluoro-phenyl ester::CHEMBL362566

SMILES Oc1c2[C@@H]3C[C@@H](CN3C(=O)Oc3ccc(F)cc3)n2c(=O)n1-c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=ZFDKGZRUOMXKBJ-YOEHRIQHSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50156504   

TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156504((1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-DHT from androgen receptor of human MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156504((1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]DHT from Androgen receptor expressed in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156504((1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,...)
Affinity DataIC50:  350nMAssay Description:Antagonist activity at Androgen receptor in human MDA-MB-453 cells measured by SEAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156504((1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,...)
Affinity DataIC50:  3.92E+3nMAssay Description:Antagonist activity at Androgen receptor in human LNCaP cells measured by SEAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156504((1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,...)
Affinity DataIC50:  3.92E+3nMAssay Description:In vitro antagonistic activity against mutant androgen receptor of LNCap cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50156504((1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,...)
Affinity DataIC50:  200nMAssay Description:In vitro antagonistic activity against androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed