BDBM50157526 CHEMBL586426::D3RKN_107::TCMDC-133606

SMILES COC(=O)c1cccc(NC(=O)NC2CCN(C2)c2ccnc(Nc3ccc(F)cc3)n2)c1

InChI Key InChIKey=LLVPDBRSUHNJQQ-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50157526   

TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157526(CHEMBL586426 | D3RKN_107 | TCMDC-133606)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to BPTF (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157526(CHEMBL586426 | D3RKN_107 | TCMDC-133606)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to BPTF (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50157526(CHEMBL586426 | D3RKN_107 | TCMDC-133606)
Affinity DataIC50:  1.00E+4nMAssay Description:D3R2024More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157526(CHEMBL586426 | D3RKN_107 | TCMDC-133606)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to 5FW-labeled BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by BODIPY-BI2536 tracer ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157526(CHEMBL586426 | D3RKN_107 | TCMDC-133606)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to 5FW-labelled BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by 19F-NMR spectraMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed