BDBM50158345 5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole::CHEMBL224720

SMILES FC(F)(F)c1sc(cc1-c1ccccc1)-c1nc(no1)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=OYMNPJXKQVTQTR-UHFFFAOYSA-N

Data  7 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50158345   

TargetSphingosine 1-phosphate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50:  4.60E+3nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataEC50:  13nMAssay Description:Inhibition of S1P1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 1(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50:  37nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50: >10nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataEC50:  270nMAssay Description:Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine 1-phosphate receptor 1(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Affinity DataIC50:  37nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)