BDBM50158845 2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-dihydroxypyrimidine-4-carboxylic acid::2-[3-({[(2-chlorobenzyl)amino]carbonyl}amino)-2-thienyl]-5,6-dihydroxypyrimidine-4-carboxylic acid::2-{3-[3-(2-Chloro-benzyl)-ureido]-thiophen-2-yl}-5-hydroxy-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid::CHEMBL175882

SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1sccc1NC(=O)NCc1ccccc1Cl

InChI Key InChIKey=COWNEZLXLGOWIV-UHFFFAOYSA-N

Data  7 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50158845   

TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataEC50:  9.30E+3nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of replication of HCV 1b BK RNA in Huh7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against HCV 2a BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of replication of HCV 1b BK RNA in Huh7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving magnesium chelationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving manganese chelationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataIC50:  45nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against hepatitis C virus polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against HCV 3a BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed