BDBM50162972 4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-amino)-[1,3,5]triazin-2-ol::CHEMBL176019

SMILES CC(C)N(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1

InChI Key InChIKey=AODUHZPEXFCKHF-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50162972   

TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of PDGF-R2 tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of beta IRK tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  280nMAssay Description:Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Insulin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of c-fms tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  180nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Mus musculus)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed