BDBM50163777 CHEMBL3799307

SMILES CN1c2ccc(cc2CS1(=O)=O)-c1cncc(Cl)c1N1CCC2(CNC(=O)O2)CC1

InChI Key InChIKey=ZNMSRFYDOSAZLZ-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50163777   

TargetCyclin-dependent kinase 8(Homo sapiens (Human))
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50163777(CHEMBL3799307)
Show SMILES CN1c2ccc(cc2CS1(=O)=O)-c1cncc(Cl)c1N1CCC2(CNC(=O)O2)CC1
Show InChI InChI=1S/C20H21ClN4O4S/c1-24-17-3-2-13(8-14(17)11-30(24,27)28)15-9-22-10-16(21)18(15)25-6-4-20(5-7-25)12-23-19(26)29-20/h2-3,8-10H,4-7,11-12H2,1H3,(H,23,26)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair