BDBM501651 US11028054, Example 25

SMILES Cc1nc2c(cc(cc2[nH]1)-c1ccc(cc1)-c1cccc(C)c1)C(O)=O

InChI Key InChIKey=FCTIFTJVCAIDRY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 501651   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM501651(US11028054, Example 25)
Affinity DataIC50:  1nMAssay Description:Inhibition of DHODH (unknown origin) using L-dihydroorotic acid as substrate preincubated for 30 mins followed by substrate addition measured every 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM501651(US11028054, Example 25)
Affinity DataIC50:  5.5nMAssay Description:Reagents used: L-Dihydroorotic acid, Sigma, D7128, 2,6-Dichloroindophenol sodium salt hydrate, sigma, D1878 Dimethyl sulfoxide (DMSO), spectroscopic ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent