BindingDB logo
myBDB logout

BDBM50172071 CHEMBL3809686

SMILES: CCc1cnc(nc1)N1CCC(CC1)C(C)CCNc1cc2OCC(=O)c2cn1

InChI Key: InChIKey=ITVGYKCGBLZFME-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50172071   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50172071
PNG
(CHEMBL3809686)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)C(C)CCNc1cc2OCC(=O)c2cn1
Show InChI InChI=1S/C22H29N5O2/c1-3-16-11-25-22(26-12-16)27-8-5-17(6-9-27)15(2)4-7-23-21-10-20-18(13-24-21)19(28)14-29-20/h10-13,15,17H,3-9,14H2,1-2H3,(H,23,24)
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 14n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHOK1 cells assessed as increase in cellular cAMP levels after 30 mins by HTRF assay


J Med Chem 59: 3579-92 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01198
BindingDB Entry DOI: 10.7270/Q28C9Z54
More data for this
Ligand-Target Pair