BDBM50172415 2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-acetamide::CHEMBL197245

SMILES CN(CCO)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1

InChI Key InChIKey=FKLOHGYBYOWNQD-UHFFFAOYSA-N

Data  5 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50172415   

TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172415(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-m...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H21Cl2N3O3/c1-13-9-20(26(2)7-8-27)25-18-5-4-15(11-16(13)18)24-21(28)12-29-19-6-3-14(22)10-17(19)23/h3-6,9-11,27H,7-8,12H2,1-2H3,(H,24,28)
Affinity DataIC50: 43nMAssay Description:Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172415(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-m...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H21Cl2N3O3/c1-13-9-20(26(2)7-8-27)25-18-5-4-15(11-16(13)18)24-21(28)12-29-19-6-3-14(22)10-17(19)23/h3-6,9-11,27H,7-8,12H2,1-2H3,(H,24,28)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergineMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172415(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-m...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H21Cl2N3O3/c1-13-9-20(26(2)7-8-27)25-18-5-4-15(11-16(13)18)24-21(28)12-29-19-6-3-14(22)10-17(19)23/h3-6,9-11,27H,7-8,12H2,1-2H3,(H,24,28)
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositolMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 2(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172415(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-m...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H21Cl2N3O3/c1-13-9-20(26(2)7-8-27)25-18-5-4-15(11-16(13)18)24-21(28)12-29-19-6-3-14(22)10-17(19)23/h3-6,9-11,27H,7-8,12H2,1-2H3,(H,24,28)
Affinity DataIC50: 10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7TM Pharma A/S

Curated by ChEMBL
LigandPNGBDBM50172415(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-m...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H21Cl2N3O3/c1-13-9-20(26(2)7-8-27)25-18-5-4-15(11-16(13)18)24-21(28)12-29-19-6-3-14(22)10-17(19)23/h3-6,9-11,27H,7-8,12H2,1-2H3,(H,24,28)
Affinity DataIC50: 2.10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair