BDBM50172473 (-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid::(2R)-2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid::(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid::(R)-2-fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid::(R)-FLURBIPROFEN::CHEMBL190083::Flurizan::Tarenflurbil

SMILES C[C@@H](C(O)=O)c1ccc(c(F)c1)-c1ccccc1

InChI Key InChIKey=SYTBZMRGLBWNTM-SNVBAGLBSA-N

Data  7 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50172473   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172473((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50172473((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...)
Affinity DataIC50:  3.07E+5nMAssay Description:Inhibition of CHAPSO-solubilized gamma-secretase isolated from human SH-SY5Y P2 cell membranes assessed as reduction in Abeta(1 to 42) peptide genera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172473((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...)
Affinity DataIC50:  2.80E+5nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50172473((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...)
Affinity DataIC50:  1.00E+5nMAssay Description:Modulation of gamma secretase (unknown origin) assessed as reduction in amyloid beta levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172473((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...)
Affinity DataIC50:  1.23E+5nMAssay Description:Concentration required to inhibit cyclooxygenase-2 in human bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50172473((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of COX2-mediated 2-arachidonoylglycerol oxygenation in LPS/IFN-gamma-stimulated mouse RAW264.7 cells assessed as 2-AG to PGE2-G/PGD2-G con...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(RAT)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172473((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...)
Affinity DataIC50:  4.40E+4nMAssay Description:Concentration required to inhibit cyclooxygenase-1 in rat bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB