BDBM50175902 1-phenyl-8-((cis,1R,2R)-2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL383539

SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@@H]1CCCC[C@@H]1c1ccccc1

InChI Key InChIKey=XMWPUEPUQVYCIC-DHIUTWEWSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50175902   

TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175902(1-phenyl-8-((cis,1R,2R)-2-phenyl-cyclohexyl)-1,3,8...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT2 cDNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175902(1-phenyl-8-((cis,1R,2R)-2-phenyl-cyclohexyl)-1,3,8...)
Affinity DataIC50:  41nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175902(1-phenyl-8-((cis,1R,2R)-2-phenyl-cyclohexyl)-1,3,8...)
Affinity DataIC50:  3.70E+3nMAssay Description:Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175902(1-phenyl-8-((cis,1R,2R)-2-phenyl-cyclohexyl)-1,3,8...)
Affinity DataEC50:  4nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed