BDBM50177858 CHEMBL3814859

SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1nc2ccccc2n1-c1ccc(NC(=O)C=C)cc1

InChI Key InChIKey=NYZWJLQCFAMHCL-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177858   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50177858(CHEMBL3814859)
Affinity DataEC50:  3.38E+3nMAssay Description:Inhibitory activity towards acetylcholine esterase (AChE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50177858(CHEMBL3814859)
Affinity DataEC50:  550nMAssay Description:Inhibition of EGFR T790M/L858R double mutant autophosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50177858(CHEMBL3814859)
Affinity DataEC50:  120nMAssay Description:Inhibition of EGFR exon19 deletion activating mutant autophosphorylation in human PC9 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed