BDBM50182013 5-bromo-N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine::CHEMBL382608::US10266549, Example 22::US10774092, Example 22

SMILES COc1cc(Nc2ncc(Br)c(Nc3ccccn3)n2)cc(OC)c1OC

InChI Key InChIKey=UWKNRTNSHIRWFJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50182013   

TargetFocal adhesion kinase 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50182013(5-bromo-N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute For Biological Studies

US Patent
LigandPNGBDBM50182013(5-bromo-N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphen...)
Affinity DataIC50: <200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute For Biological Studies

US Patent
LigandPNGBDBM50182013(5-bromo-N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphen...)
Affinity DataIC50: <200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In DepthDetails US Patent