BDBM50183711 CHEMBL208009::N-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide

SMILES Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCNCC2)c2ccccc2n1

InChI Key InChIKey=BODLESUVCQEUII-UHFFFAOYSA-N

Data  13 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50183711   

TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  18nMAssay Description:Binding affinity to MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  91nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  97nMAssay Description:Binding affinity to ADAMTS5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  217nMAssay Description:Binding affinity to MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  776nMAssay Description:Binding affinity to ADAMTS1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  1.83E+3nMAssay Description:Binding affinity to ADAMTS4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi: >2.13E+3nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi: >3.33E+3nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi: >4.95E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi: >5.03E+3nMAssay Description:Binding affinity to MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi: >5.29E+3nMAssay Description:Binding affinity to MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi: >5.55E+3nMAssay Description:Binding affinity to MMP16More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi: >7.09E+3nMAssay Description:Binding affinity to MMP15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataIC50:  36nMAssay Description:Inhibition of LPS-stimulated TNFalpha production in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed