BDBM50184071 (R)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)piperidine-1-carboxamide::CHEMBL424864

SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1

InChI Key InChIKey=FJVIXLDHHTWOCN-MHZLTWQESA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50184071   

TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Department Of Medicinal Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50184071((R)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-...)
Affinity DataKi:  44nMAssay Description:Displacement of [125I]CGRP from human cloned CLR/RAMP1 receptor expressed in E10 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184071((R)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-...)
Affinity DataKi:  48nMAssay Description:Displacement of [125I]CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184071((R)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-...)
Affinity DataIC50:  34nMAssay Description:Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Homo sapiens (Human))
Department Of Medicinal Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50184071((R)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-...)
Affinity DataIC50:  38nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed