BDBM50185795 5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-indole::CHEMBL438965

SMILES Cc1[nH]c2ccc(Cl)cc2c1C1CCN(Cc2cccc3ccccc23)CC1

InChI Key InChIKey=AAVKSWRCTYHNEP-UHFFFAOYSA-N

Data  4 KI

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50185795   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50185795(5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)pipe...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1CCN(Cc2cccc3ccccc23)CC1
Show InChI InChI=1S/C25H25ClN2/c1-17-25(23-15-21(26)9-10-24(23)27-17)19-11-13-28(14-12-19)16-20-7-4-6-18-5-2-3-8-22(18)20/h2-10,15,19,27H,11-14,16H2,1H3
Affinity DataKi:  750nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50185795(5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)pipe...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1CCN(Cc2cccc3ccccc23)CC1
Show InChI InChI=1S/C25H25ClN2/c1-17-25(23-15-21(26)9-10-24(23)27-17)19-11-13-28(14-12-19)16-20-7-4-6-18-5-2-3-8-22(18)20/h2-10,15,19,27H,11-14,16H2,1H3
Affinity DataKi:  880nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50185795(5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)pipe...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1CCN(Cc2cccc3ccccc23)CC1
Show InChI InChI=1S/C25H25ClN2/c1-17-25(23-15-21(26)9-10-24(23)27-17)19-11-13-28(14-12-19)16-20-7-4-6-18-5-2-3-8-22(18)20/h2-10,15,19,27H,11-14,16H2,1H3
Affinity DataKi: >5.00E+3nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50185795(5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)pipe...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1CCN(Cc2cccc3ccccc23)CC1
Show InChI InChI=1S/C25H25ClN2/c1-17-25(23-15-21(26)9-10-24(23)27-17)19-11-13-28(14-12-19)16-20-7-4-6-18-5-2-3-8-22(18)20/h2-10,15,19,27H,11-14,16H2,1H3
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]DDPDE from delta opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair