BDBM501860 US11028067, Example 1::US11028067, Example 8

SMILES COc1ccc(c(n1)S(=O)(=O)c1ccccn1)[N+]([O-])=O

InChI Key InChIKey=AMOBUAVGNXPBRW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501860   

TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501860(US11028067, Example 1 | US11028067, Example 8)
Affinity DataIC50:  26.8nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501860(US11028067, Example 1 | US11028067, Example 8)
Affinity DataIC50:  5.5nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501860(US11028067, Example 1 | US11028067, Example 8)
Affinity DataIC50:  6.42E+4nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent