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BDBM50186807 3-[4-(3'-cyano-biphenyl-4-yl)-1-diethylsulfamoyl-piperidin-4-yl]-N-(3,4-difluoro-phenyl)-propionamide::CHEMBL212671

SMILES: CCN(CC)S(=O)(=O)N1CCC(CCC(=O)Nc2ccc(F)c(F)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N

InChI Key: InChIKey=ANFVQBDHMFHTNG-UHFFFAOYSA-N

Data: 2 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50186807   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50186807
PNG
(3-[4-(3'-cyano-biphenyl-4-yl)-1-diethylsulfamoyl-p...)
Show SMILES CCN(CC)S(=O)(=O)N1CCC(CCC(=O)Nc2ccc(F)c(F)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C31H34F2N4O3S/c1-3-36(4-2)41(39,40)37-18-16-31(17-19-37,15-14-30(38)35-27-12-13-28(32)29(33)21-27)26-10-8-24(9-11-26)25-7-5-6-23(20-25)22-34/h5-13,20-21H,3-4,14-19H2,1-2H3,(H,35,38)
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KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
193n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay


Bioorg Med Chem Lett 16: 3668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.061
BindingDB Entry DOI: 10.7270/Q2251HT9
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50186807
PNG
(3-[4-(3'-cyano-biphenyl-4-yl)-1-diethylsulfamoyl-p...)
Show SMILES CCN(CC)S(=O)(=O)N1CCC(CCC(=O)Nc2ccc(F)c(F)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C31H34F2N4O3S/c1-3-36(4-2)41(39,40)37-18-16-31(17-19-37,15-14-30(38)35-27-12-13-28(32)29(33)21-27)26-10-8-24(9-11-26)25-7-5-6-23(20-25)22-34/h5-13,20-21H,3-4,14-19H2,1-2H3,(H,35,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>3.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human MCHR2 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay


Bioorg Med Chem Lett 16: 3668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.061
BindingDB Entry DOI: 10.7270/Q2251HT9
More data for this
Ligand-Target Pair