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BDBM50186836 4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-carboxylic acid amide::CHEMBL377270

SMILES: NC(=O)c1cccc(c1)-c1ccc(cc1)C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)=C1CCN(CC2CC2)CC1

InChI Key: InChIKey=AGMAFERLZIQTJG-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50186836   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50186836
PNG
(4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-f...)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(cc1)C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)=C1CCN(CC2CC2)CC1
Show InChI InChI=1S/C31H28F4N4O/c32-25-16-27-26(15-24(25)31(33,34)35)37-30(38-27)28(21-10-12-39(13-11-21)17-18-4-5-18)20-8-6-19(7-9-20)22-2-1-3-23(14-22)29(36)40/h1-3,6-9,14-16,18H,4-5,10-13,17H2,(H2,36,40)(H,37,38)
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PC sid
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Similars

Article
PubMed
77n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay


Bioorg Med Chem Lett 16: 3674-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.062
BindingDB Entry DOI: 10.7270/Q2XG9QQB
More data for this
Ligand-Target Pair