BDBM50187063 CHEMBL379386::GNF-PF-2722::N2-(4-bromophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine

SMILES Brc1ccc(Nc2nc(NCc3ccco3)c3ccccc3n2)cc1

InChI Key InChIKey=WYDGHRZFSRBHSA-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50187063   

TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50187063(CHEMBL379386 | GNF-PF-2722 | N2-(4-bromophenyl)-N4...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Mus musculus)
Research Center Idrtech

Curated by ChEMBL
LigandPNGBDBM50187063(CHEMBL379386 | GNF-PF-2722 | N2-(4-bromophenyl)-N4...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed