BDBM50188272 7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole::CHEMBL212084

SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1

InChI Key InChIKey=AQFXVMZZFFFSCG-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50188272   

TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  169nMAssay Description:Inhibition of FLT4 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PDGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  1.47E+5nMAssay Description:Inhibition of KDR-mediated biotin-Ahx-AEEEYFFLFA-amide substrate phosphorylation in presence of 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1/2/3/4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  3.44E+4nMAssay Description:Inhibition of FGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cMet by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  293nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  254nMAssay Description:Inhibition of CYP3A4 in human liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  103nMAssay Description:Inhibition of cKit by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  2.11E+4nMAssay Description:Inhibition of Lck by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of Tie2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  147nMAssay Description:Inhibition of KDR at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  601nMAssay Description:Inhibition of FLT1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed