BDBM501891 US11028075, Example 24

SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)c1cc(Cl)cc(c1)C(F)(F)F

InChI Key InChIKey=ILCQSSPNYDCQDL-FSJXIACGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 501891   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM501891(US11028075, Example 24)
Affinity DataIC50:  0.383nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM501891(US11028075, Example 24)
Affinity DataIC50:  0.583nMAssay Description:Saturation experiments. A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent