BDBM50189311 4,4''-(1,2-Phenylenebis(Methylene))Bis(Oxy)Dibenzimidamide::CHEMBL181480

SMILES: NC(=N)c1ccc(OCc2ccccc2COc2ccc(cc2)C(N)=N)cc1

InChI Key: InChIKey=DBQNFQRZGKINAU-UHFFFAOYSA-N

Data: 5 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50189311   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Trypsin (Homo sapiens (Human))	BDBM50189311 (4,4''-(1,2-Phenylenebis(Methylene))Bis(Oxy)Dibenzi...) Show SMILES NC(=N)c1ccc(OCc2ccccc2COc2ccc(cc2)C(N)=N)cc1 Show InChI InChI=1S/C22H22N4O2/c23-21(24)15-5-9-19(10-6-15)27-13-17-3-1-2-4-18(17)14-28-20-11-7-16(8-12-20)22(25)26/h1-12H,13-14H2,(H3,23,24)(H3,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	221	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of human trypsin using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis				Bioorg Med Chem Lett 26: 3741-5 (2016) Article DOI: 10.1016/j.bmcl.2016.05.071 BindingDB Entry DOI: 10.7270/Q29025QN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50189311 (4,4''-(1,2-Phenylenebis(Methylene))Bis(Oxy)Dibenzi...) Show SMILES NC(=N)c1ccc(OCc2ccccc2COc2ccc(cc2)C(N)=N)cc1 Show InChI InChI=1S/C22H22N4O2/c23-21(24)15-5-9-19(10-6-15)27-13-17-3-1-2-4-18(17)14-28-20-11-7-16(8-12-20)22(25)26/h1-12H,13-14H2,(H3,23,24)(H3,25,26)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	279	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of human thrombin using Cbz-Gly-Gly-Arg-AMC as substrate after 20 mins by fluorimetric analysis				Bioorg Med Chem Lett 26: 3741-5 (2016) Article DOI: 10.1016/j.bmcl.2016.05.071 BindingDB Entry DOI: 10.7270/Q29025QN
					More data for this Ligand-Target Pair
Matriptase (Homo sapiens (Human))	BDBM50189311 (4,4''-(1,2-Phenylenebis(Methylene))Bis(Oxy)Dibenzi...) Show SMILES NC(=N)c1ccc(OCc2ccccc2COc2ccc(cc2)C(N)=N)cc1 Show InChI InChI=1S/C22H22N4O2/c23-21(24)15-5-9-19(10-6-15)27-13-17-3-1-2-4-18(17)14-28-20-11-7-16(8-12-20)22(25)26/h1-12H,13-14H2,(H3,23,24)(H3,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.28E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of human matriptase using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis				Bioorg Med Chem Lett 26: 3741-5 (2016) Article DOI: 10.1016/j.bmcl.2016.05.071 BindingDB Entry DOI: 10.7270/Q29025QN
					More data for this Ligand-Target Pair
Transmembrane protease serine 6 (Homo sapiens (Human))	BDBM50189311 (4,4''-(1,2-Phenylenebis(Methylene))Bis(Oxy)Dibenzi...) Show SMILES NC(=N)c1ccc(OCc2ccccc2COc2ccc(cc2)C(N)=N)cc1 Show InChI InChI=1S/C22H22N4O2/c23-21(24)15-5-9-19(10-6-15)27-13-17-3-1-2-4-18(17)14-28-20-11-7-16(8-12-20)22(25)26/h1-12H,13-14H2,(H3,23,24)(H3,25,26)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis				Bioorg Med Chem Lett 26: 3741-5 (2016) Article DOI: 10.1016/j.bmcl.2016.05.071 BindingDB Entry DOI: 10.7270/Q29025QN
					More data for this Ligand-Target Pair
Coagulation factor X (Bos taurus)	BDBM50189311 (4,4''-(1,2-Phenylenebis(Methylene))Bis(Oxy)Dibenzi...) Show SMILES NC(=N)c1ccc(OCc2ccccc2COc2ccc(cc2)C(N)=N)cc1 Show InChI InChI=1S/C22H22N4O2/c23-21(24)15-5-9-19(10-6-15)27-13-17-3-1-2-4-18(17)14-28-20-11-7-16(8-12-20)22(25)26/h1-12H,13-14H2,(H3,23,24)(H3,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of bovine factor 10a using Boc-Ile-Glu-Gly-Arg-AMC as substrate after 20 mins by fluorimetric analysis				Bioorg Med Chem Lett 26: 3741-5 (2016) Article DOI: 10.1016/j.bmcl.2016.05.071 BindingDB Entry DOI: 10.7270/Q29025QN
					More data for this Ligand-Target Pair