BDBM50189516 6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8(9H)-one::6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol::9-benzyl-2-(2-methoxyethoxy)-8-oxoadenine::9-benzyl-2-methoxyethoxy-8-oxoadenine::CHEMBL210884::SM-360320

SMILES COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1

InChI Key InChIKey=YYCDGEZXHXHLGW-UHFFFAOYSA-N

Data  1 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50189516   

TargetToll-like receptor 7(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50189516(6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8(9H...)
Affinity DataEC50:  399nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assayMore data for this Ligand-Target Pair
LigandPNGBDBM50189516(6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8(9H...)
Affinity DataIC50:  2.81E+3nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50189516(6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8(9H...)
Affinity DataEC50:  944nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of IN-12 stimulationMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Dainippon Sumitomo Pharma

Curated by ChEMBL
LigandPNGBDBM50189516(6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8(9H...)
Affinity DataEC50:  1.17E+3nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair