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BDBM50190270 4'-trifluoromethyl-biphenyl-4-carboxylic acid methyl-((S)-1-{(R)-3-[methyl-(4-methyl-cyclohexyl)-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl)-amide::CHEMBL385959

SMILES: CC1CCC(CC1)N(C)[C@@H]1CCN(C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=ALGLCHGXJVZFRW-BYOMPTMESA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50190270   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50190270
PNG
(4'-trifluoromethyl-biphenyl-4-carboxylic acid meth...)
Show SMILES CC1CCC(CC1)N(C)[C@@H]1CCN(C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H41F3N4O2/c1-22-4-14-27(15-5-22)36(2)28-16-18-38(20-28)31(41)39-19-17-29(21-39)37(3)30(40)25-8-6-23(7-9-25)24-10-12-26(13-11-24)32(33,34)35/h6-13,22,27-29H,4-5,14-21H2,1-3H3/t22?,27?,28-,29+/m1/s1
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PC sid
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Similars

Article
PubMed
29n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc

Curated by ChEMBL


Assay Description
Displacement of [125I-Tyr13]MCH from human MCHR1 expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4450-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.045
BindingDB Entry DOI: 10.7270/Q23J3CKC
More data for this
Ligand-Target Pair