BDBM50191625 CHEMBL208605::rac-3-{ethyl[4-(5-fluoro-1H-indol-3-yl)butyl]amino}-8-fluorochromane-5-carboxamide
SMILES CCN(CCCCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(N)=O)c2C1
InChI Key InChIKey=NGERZXQKWVCCOB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50191625
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]paroxetine from 5-HT transporter in Sprague-Dawley rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataIC50: 24.1nMAssay Description:Inhibition of [3H]5-HT uptake at human 5-HT transporter expressed in Jar cellsMore data for this Ligand-Target Pair