BDBM50191974 CHEMBL3913766

SMILES CN1CCN(CC1)c1ccccc1CNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(ccn23)-c2cnn(C)c2)c1

InChI Key InChIKey=JJKABNROBRKPQT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50191974   

TargetPlatelet-derived growth factor receptor beta(Rattus norvegicus)
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191974(CHEMBL3913766)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of PDGFR-beta driven proliferation of rat A10 cells after 68 hrs in presence of rat recombinant PDGF-BB by cell titer-glo luminescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research (Nibr)

Curated by ChEMBL
LigandPNGBDBM50191974(CHEMBL3913766)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed