BDBM501920 US11028075, Example 53

SMILES CN(C)[C@@H]1C[C@@]2(C(C[C@H]1N(C)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1)C2(Cl)Cl)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=MQQOBEJPPXNGCH-NPRFCDLBSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 501920   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM501920(US11028075, Example 53)
Affinity DataIC50:  1.86nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM501920(US11028075, Example 53)
Affinity DataIC50:  46.2nMAssay Description:Saturation experiments. A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent