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BDBM50194528 CHEMBL411970::methyl 3-(4-cyanophenyl)-5-(diisopropylamino)-5-oxo-4-(pyridin-3-yl)pentanoate

SMILES: COC(=O)CC(C(C(=O)N(C(C)C)C(C)C)c1cccnc1)c1ccc(cc1)C#N

InChI Key: InChIKey=KOLKOMBMURXIPR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194528   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194528
PNG
(CHEMBL411970 | methyl 3-(4-cyanophenyl)-5-(diisopr...)
Show SMILES COC(=O)CC(C(C(=O)N(C(C)C)C(C)C)c1cccnc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C24H29N3O3/c1-16(2)27(17(3)4)24(29)23(20-7-6-12-26-15-20)21(13-22(28)30-5)19-10-8-18(14-25)9-11-19/h6-12,15-17,21,23H,13H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 215n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair