BDBM501946 US11028075, Example 79

SMILES CN(C)[C@H]1C[C@H](CC[C@@H]1Oc1ccc(cc1F)S(=O)(=O)Nc1ccncn1)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=ZHUVZXCESSXTSO-HYVJGQCMSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 501946   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM501946(US11028075, Example 79)
Affinity DataIC50:  18nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM501946(US11028075, Example 79)
Affinity DataIC50:  223nMAssay Description:Saturation experiments. A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent