BDBM501951 US11028075, Example 84

SMILES Fc1ccc(cc1C(F)(F)F)[C@H]1CC[C@H](Nc2cc(F)c(cc2F)S(=O)(=O)Nc2ccncn2)[C@H](C1)N1CCCC1

InChI Key InChIKey=ZYJAZKZKCCTNAJ-OWSXEPHWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 501951   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM501951(US11028075, Example 84)
Affinity DataIC50:  0.520nMAssay Description:The following voltage clamp electrophysiology studies are performed on representative compounds using cells heterologously expressing Nav1.7 or Nav1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM501951(US11028075, Example 84)
Affinity DataIC50:  0.877nMAssay Description:Saturation experiments. A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent