BDBM50196122 CHEMBL217366::GNF-PF-3878::N-(4-(4-ethylpiperazin-1-yl)phenyl)acridin-9-amine::TCMDC-124255

SMILES CCN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1

InChI Key InChIKey=CUVBGWMAORETGV-UHFFFAOYSA-N

Data  4 KI

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50196122   

TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Timisoara of the Romanian Academy

Curated by ChEMBL
LigandPNGBDBM50196122(CHEMBL217366 | GNF-PF-3878 | N-(4-(4-ethylpiperazi...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C25H26N4/c1-2-28-15-17-29(18-16-28)20-13-11-19(12-14-20)26-25-21-7-3-5-9-23(21)27-24-10-6-4-8-22(24)25/h3-14H,2,15-18H2,1H3,(H,26,27)
Affinity DataKi:  37.0nMAssay Description:Binding affinity to human cloned Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Timisoara of the Romanian Academy

Curated by ChEMBL
LigandPNGBDBM50196122(CHEMBL217366 | GNF-PF-3878 | N-(4-(4-ethylpiperazi...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C25H26N4/c1-2-28-15-17-29(18-16-28)20-13-11-19(12-14-20)26-25-21-7-3-5-9-23(21)27-24-10-6-4-8-22(24)25/h3-14H,2,15-18H2,1H3,(H,26,27)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Juvantia Pharma Ltd

Curated by ChEMBL
LigandPNGBDBM50196122(CHEMBL217366 | GNF-PF-3878 | N-(4-(4-ethylpiperazi...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C25H26N4/c1-2-28-15-17-29(18-16-28)20-13-11-19(12-14-20)26-25-21-7-3-5-9-23(21)27-24-10-6-4-8-22(24)25/h3-14H,2,15-18H2,1H3,(H,26,27)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]rauwolscine from human ADRA2B expressed in S115 cellsMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Juvantia Pharma Ltd

Curated by ChEMBL
LigandPNGBDBM50196122(CHEMBL217366 | GNF-PF-3878 | N-(4-(4-ethylpiperazi...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C25H26N4/c1-2-28-15-17-29(18-16-28)20-13-11-19(12-14-20)26-25-21-7-3-5-9-23(21)27-24-10-6-4-8-22(24)25/h3-14H,2,15-18H2,1H3,(H,26,27)
Affinity DataKi:  3.60E+3nMAssay Description:Displacement of [3H]rauwolscine from human ADRA2A expressed in S115 cellsMore data for this Ligand-Target Pair