BDBM50197277 CHEMBL3972086
SMILES Cc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1F
InChI Key InChIKey=GOMFFTZBKYVUOE-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50197277
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Soochow University
Curated by ChEMBL
Soochow University
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells after 48 hrs by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Bodipy-cyclopamine binding to human Smo expressed in human U2OS cells after 2 hrs by high content fluorescence imaging analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse NIH3T3 cells expressing GRE-Luc reporter gene assessed as inhibition of SAG-induced GR...More data for this Ligand-Target Pair