BDBM50197277 CHEMBL3972086

SMILES Cc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1F

InChI Key InChIKey=GOMFFTZBKYVUOE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50197277   

TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50197277(CHEMBL3972086)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells after 48 hrs by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50197277(CHEMBL3972086)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Bodipy-cyclopamine binding to human Smo expressed in human U2OS cells after 2 hrs by high content fluorescence imaging analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50197277(CHEMBL3972086)
Affinity DataIC50:  71nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse NIH3T3 cells expressing GRE-Luc reporter gene assessed as inhibition of SAG-induced GR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed