BDBM50200384 CHEMBL3968533::US9763922, Example 299

SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1)nn2[C@@H]1CCOC1

InChI Key InChIKey=NKOJNOBJGYTLLZ-QGZVFWFLSA-N

Data  17 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50200384   

TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50:  20nMAssay Description:Displacement of biotinylated ligand from CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50:  6.25E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 8(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD8 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged PCAF (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50:  400nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to CBP/EP300 (unknown origin) expressed in HEK293 cells measured after overnight incubation by lucifer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataEC50:  69nMAssay Description:Inhibition of CBP/EP300 in human MOLM16 cells assessed as decrease in MYC expression measured after 4 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50:  30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BPTF (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRPF1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50:  1.20E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged TAF1 bromodomain 2 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain adjacent to zinc finger domain protein 2B(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BAZ2B (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD9 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged TAF1 bromodomain 1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataEC50:  910nMAssay Description:Inhibition of CBP/EP300 in human MV4-11 cells assessed as inhibition of MYC expression measured after 4 hrs by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CECR2 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50:  1.30E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50:  40nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone acetyltransferase KAT2A(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged GCN5 long isoform (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed