BDBM50201796 CHEBI:5677::Hernandezine
SMILES [H][C@]12Cc3ccc(Oc4cc(C[C@]5([H])N(C)CCc6c(OC)c(OC)c(OC)c(Oc7cc1c(CCN2C)cc7OC)c56)ccc4OC)cc3
InChI Key InChIKey=FUZMQNZACIFDBL-KYJUHHDHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50201796
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Binding affinity to Vanadate-sensitive ABCB1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.06E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 571nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 3.22E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 304nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 50 nM a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 2.66E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 5...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 50 nM...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 200 n...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 500 nM ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 100 n...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 200 n...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 224nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 118nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 200 nM ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human ABCB1-mediated efflux transfected in HEK293 cells assessed as accumulation of fluorescent dye by calcein-AM dye based FACS analys...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 100 n...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 500 n...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 188nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of colchicine-induced cytotoxicity by measuring colchicine IC50 at 100 nM ...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 205nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 50 nM...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 500 n...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 970nMAssay Description:Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 a...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of human ABCB1 transfected in HEK293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 1...More data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Chang Gung Memorial Hospital
Curated by ChEMBL
Chang Gung Memorial Hospital
Curated by ChEMBL
Affinity DataIC50: 3.83E+4nMAssay Description:Inhibition of human ABCC1 transfected in HEK293 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 at 500 n...More data for this Ligand-Target Pair