BDBM50202418 CHEMBL374580::methyl 3,3'-difluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]-cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate

SMILES COC(=O)c1c(F)cccc1-c1ccc([C@@H](C)NC(=O)C2(CC2)NC(=O)C(F)(F)F)c(F)c1

InChI Key InChIKey=PONSWFOKRNNNTR-LLVKDONJSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50202418   

TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50202418(CHEMBL374580 | methyl 3,3'-difluoro-4'-{(1R)-1-[({...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]des-Arg10 Leu9 kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50202418(CHEMBL374580 | methyl 3,3'-difluoro-4'-{(1R)-1-[({...)
Affinity DataIC50:  1.90nMAssay Description:Activity at human bradykinin B1 receptor assessed as inhibition of Des-arg kallidin-induced increase of cytosolic calcium in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed