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BDBM50203110 CHEMBL3914791

SMILES: [I-].C[n+]1c2-c3ccccc3-c3nc(cc(c23)c2ccccc12)-c1ccccc1

InChI Key: InChIKey=IRCPLCUXOZWFBG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50203110   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA topoisomerase I (Topo I)


(Homo sapiens (Human))
BDBM50203110
PNG
(CHEMBL3914791)
Show SMILES [I-].C[n+]1c2-c3ccccc3-c3nc(cc(c23)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H17N2/c1-27-22-14-8-7-11-17(22)20-15-21(16-9-3-2-4-10-16)26-24-18-12-5-6-13-19(18)25(27)23(20)24/h2-15H,1H3/q+1
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Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DNA topoisomerase 1 using pHOT1 as substrate after 30 mins by agarose gel electrophoresis


Bioorg Med Chem 24: 6119-6130 (2016)


Article DOI: 10.1016/j.bmc.2016.02.028
BindingDB Entry DOI: 10.7270/Q2BG2QZJ
More data for this
Ligand-Target Pair