BDBM50203535 (6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino[1,2-a]indol-2(1H)-ylcarbonyl)-5-azaspiro[2.5]octane-7-carboxamide::CHEMBL426388

SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCN2C(Cc3ccccc23)C1

InChI Key InChIKey=RINLHBFSMHCDCB-ZWBSKUQPSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50203535   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50:  330nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50:  280nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)
Affinity DataIC50:  350nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed