BDBM50211257 CHEMBL3895863::US10583137, Compound 14
SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1
InChI Key InChIKey=GVLOFRPVRYAFKI-VSGBNLITSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50211257
Affinity DataKi: 0.270nMAssay Description:Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of MB064 probe binding to ABHD6 in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: <400nMAssay Description:Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...More data for this Ligand-Target Pair
Affinity DataIC50: <400nMAssay Description:Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...More data for this Ligand-Target Pair
Affinity DataIC50: 126nMAssay Description:Inhibition of ABHD6 in mouse brain membrane using HT-01 probe as substrate incubated for 30 mins by gel based competitive ABPP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant ABHD6More data for this Ligand-Target Pair
Affinity DataIC50: 0.631nMAssay Description:Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...More data for this Ligand-Target Pair
Affinity DataIC50: >1nMAssay Description:Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...More data for this Ligand-Target Pair