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BDBM50214148 CHEMBL283395

SMILES: CCN(CC)CCNc1ccc(CNS(C)(=O)=O)c2sc3ccccc3c(=O)c12

InChI Key: InChIKey=NAMOLZVVTPNNTE-UHFFFAOYSA-N

Data: 2 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50214148   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA topoisomerase II


(Homo sapiens (Human))
BDBM50214148
PNG
(CHEMBL283395)
Show SMILES CCN(CC)CCNc1ccc(CNS(C)(=O)=O)c2sc3ccccc3c(=O)c12
Show InChI InChI=1S/C21H27N3O3S2/c1-4-24(5-2)13-12-22-17-11-10-15(14-23-29(3,26)27)21-19(17)20(25)16-8-6-7-9-18(16)28-21/h6-11,22-23H,4-5,12-14H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.00E+3n/an/an/an/a



Sanofi Winthrop Inc.

Curated by ChEMBL


Assay Description
In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.


J Med Chem 41: 3645-54 (1998)


Article DOI: 10.1021/jm9708083
BindingDB Entry DOI: 10.7270/Q2GB26SZ
More data for this
Ligand-Target Pair
DNA topoisomerase II


(Homo sapiens (Human))
BDBM50214148
PNG
(CHEMBL283395)
Show SMILES CCN(CC)CCNc1ccc(CNS(C)(=O)=O)c2sc3ccccc3c(=O)c12
Show InChI InChI=1S/C21H27N3O3S2/c1-4-24(5-2)13-12-22-17-11-10-15(14-23-29(3,26)27)21-19(17)20(25)16-8-6-7-9-18(16)28-21/h6-11,22-23H,4-5,12-14H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

n/an/an/an/a 3.00E+3n/an/an/an/a


TBA

Assay Description
Inhibition of topoisomerase II purified from HeLa cells


Citation and Details

BindingDB Entry DOI: 10.7270/Q2DN4760
More data for this
Ligand-Target Pair